St Charles Real Estate | St Charles Commercial Properties for Sale

Rare opportunity to own a distinctive commercial property in the Business District of St. Charles. Ideally positioned on Second Street between Historic Main Street and Frenchtown, this approximately 2,600 SF Designated Historic Building offers the character and charm of historic St. Charles with the functionality and flexibility of a professional office setting. The main level features four flexible office/work spaces, kitchen and half bath, while the upper level provides three additional spaces, kitchenette and half bath. The walk-out basement offers additional storage or flexible-use space. Private parking includes a lot for 8 cars plus 2 additional spaces near the side entrance. Two entrances provide added flexibility for multiple work areas or potential shared-use configurations. Located next to the County Courthouse, this is an ideal setting for a law firm, real estate office, financial or insurance professional, or other professional business. Adding to the appeal is the significant investment and transformation underway throughout the surrounding area. Just steps from the new City Centre Complex (C3), the property sits in the path of major improvements designed to better connect Historic Main Street, Second Street, Frenchtown and the riverfront. Own a piece of historic St. Charles while positioning your business for what's next.

424 N 2nd St, St Charles

$400,000

ACTIVE Status ⋅ Brenda Lowder

Great Retail or Office site with 170+/- SF of Hwy 94 Exposure located ¼ mile to Interstate 70 and 1/3 mile to Lindenwood University, across from QT and surrounded by retail and service businesses. Service the county and city business district and SSM St. Joseph’s Hospital. Site plan for 7,260 SF building or concepts for fast food drive-thru. C-3 Zoning, graded, utilities to site. Possible additional ground if needed. Location: City, Corner Location, High Traffic

2255 First Capitol, St Charles

$235,000

ACTIVE Status ⋅ Douglas Meyer

SHORT-TERM RENTAL + FLEXIBLE COMMERCIAL USE! This unique historic brick bungalow offers an excellent opportunity for an owner-user, investor, or entrepreneur looking for an affordable commercial property with flexibility. Located within the City of St. Charles and zoned C-3 Highway District Commercial, the property is currently being operated as a permitted short-term rental/Guest House. Due to the existing zoning and Guest House permit, the property may be sold and continue its current short-term-rental use. The charming bungalow beautifully blends historic character with modern convenience. Original wood floors, arched doorways, and beautiful wood trim showcase its timeless appeal, while thoughtful updates include stylish barn doors leading to the bedroom and bathroom, granite kitchen countertops, an updated bathroom, vinyl windows, and a high-efficiency furnace. The property also features a spacious two-car-sized storage shed and 4+ concrete off-street parking spaces, providing valuable additional storage and parking. But the possibilities don't stop with the existing Guest House use. C-3 Highway District Commercial zoning provides a wide range of potential business uses. Depending on applicable city regulations and approvals, possibilities may include office, retail, animal-related services, storage, and other permitted commercial uses. A list of C-3 permitted uses from the City of St. Charles zoning regulations will be available with the listing for agents and buyers to review. Existing furniture and fixtures are included with the property, including the refrigerator and the washer/dryer located in the small partially finished basement room. Whether you continue the successful short-term-rental/Guest House use, establish your own business, or explore another permitted use, this is an opportunity to own an affordable piece of commercial real estate in a great location. Come see what YOU can make of this property!

2009 N 3rd St, St Charles

$950,000

ACTIVE Status ⋅ Ben Cherry

334 N Main Street presents a rare opportunity to acquire a historic, income-producing mixed-use building in the heart of downtown St. Charles. Originally constructed in 1835, this brick building totals approximately 5,712 square feet across two floors plus a full lower level of approximately 2,850 square feet, situated on a 0.093-acre parcel with direct N Main Street frontage. The upper floor is fully utilized as Airbnb and shorter-term apartment units, generating a true net operating income of approximately $42,000. The first floor offers approximately 2,862 square feet of turn-key gym space – a dramatic 90-foot-deep open floor plate with two private offices and a restroom – supported by locker rooms and showers in the lower level. This space is being marketed for lease at $25.00 per square foot NNN; a signed gym tenant would add roughly $70,000 of annual income, more than doubling NOI and giving an investor immediate, executable upside on day one. At the $950,000 asking price, that translates to approximately $166 per square foot – well below replacement cost for historic Main Street product. Zoned General Commercial (AB2), the property supports a broad range of retail, service, fitness, hospitality, and residential uses. The location benefits from 77,283 vehicles per day along the adjacent Riverside Drive corridor and a Walk Score of 79, reflecting the district’s exceptional year-round pedestrian activity. Downtown St. Charles draws millions of visitors annually with its brick-paved streets, riverfront festivals – including the nationally recognized Christmas Traditions celebration – and its position along the Missouri River and Katy Trail. Neighbors include Mov on Main, Climb So iLL at the Steel Shop, and the district’s dense collection of boutiques, restaurants, wineries, and entertainment venues, with SSM Health St. Joseph Hospital anchoring the corridor to the south. With stabilized short-term rental income upstairs, a turn-key gym opportunity below, and irreplaceable Main Street real estate, 334 N Main is a compelling acquisition for investors seeking both current cash flow and meaningful near-term growth.

334 N Main St, St Charles

$1,550,000

ACTIVE Status ⋅ Ben Cherry

Located in the heart of Saint Charles’ Historic Main Street District, 213 N Main Street presents a rare opportunity to acquire a fully stabilized, income-producing mixed-use asset in one of Missouri’s most vibrant and heavily visited commercial corridors. This circa-1890 brick building offers 4,524 square feet of well-utilized space and generates a true net operating income of approximately $83,000 annually, translating to an attractive 5.35% cap rate at the $1,550,000 asking price. The ground floor is home to Reset, an established clothing and shoe resale retailer that benefits from the district’s steady, year-round foot traffic. Above the retail level, the upper units operate as income-producing apartment and Airbnb rentals, capitalizing on Saint Charles’ thriving tourism economy and persistent demand for short-term accommodations near the riverfront. This blend of retail and residential income creates a diversified rent roll that insulates ownership from single-tenant risk and delivers dependable cash flow from day one. Unlike value-add offerings that require capital and lease-up time, 213 N Main is a turnkey investment: the work has been done, the income is in place, and a new owner simply steps into a performing asset in an irreplaceable location. Historic Main Street draws visitors year-round with its brick-paved streetscape, boutique shopping, dining, and signature festivals, including the nationally recognized Christmas Traditions celebration. The property sits steps from the Missouri Riverfront, Frontier Park, and the First Missouri State Capitol Historic Site, with a nearby traffic count of 77,283 vehicles per day and a Walk Score of 79/100. Downtown Saint Charles continues to benefit from sustained public and private investment, and surrounding values have appreciated 10% over the past two years. For investors seeking stable, diversified income with long-term appreciation in a proven historic district where buildings rarely trade hands, 213 N Main Street is a compelling, low-friction addition to any portfolio.

213 N Main St, St Charles

$800,000

ACTIVE Status ⋅ Ben Cherry

Positioned in the heart of Saint Charles’ Historic Main Street District, 138 N Main Street offers investors a rare combination of stable in-place income and significant value-add upside. This circa-1890 brick building totals 5,077 square feet on a 0.16-acre parcel with 28 feet of Main Street frontage and Central Business District (AA4) zoning that supports a wide range of commercial and residential uses. The ground floor is anchored by La Tia and Pancho’s Cantina Grill, a beloved local restaurant that has operated at this location for a full decade. The tenant generates $45,000 in annual net operating income, providing dependable day-one cash flow at an attractive 5.6% cap rate on the $800,000 asking price. The real story, however, is the untapped potential upstairs. The second and third floors are primed for renovation into apartment units, allowing an investor to capitalize on strong demand for downtown living along one of the region’s most walkable corridors (79/100 Walk Score). Converting the upper floors to residential would meaningfully increase income while diversifying the rent roll across commercial and multifamily uses, an increasingly rare opportunity in a district where historic buildings seldom trade hands. Historic Main Street draws visitors year-round for its brick-paved streetscape, boutique shopping, dining, and signature festivals, including the nationally recognized Christmas Traditions celebration. The property sits steps from the Missouri Riverfront, Frontier Park, and the First Missouri State Capitol Historic Site, with a traffic count of 77,283 vehicles per day nearby. Ongoing public and private investment throughout downtown Saint Charles continues to strengthen values, with the surrounding neighborhood appreciating 10% over the last two years. Whether held as a stabilized income asset with a proven restaurant tenant or repositioned as a fully realized mixed-use retail-and-residential property, 138 N Main Street represents a compelling investment opportunity in an irreplaceable, high-visibility location on one of Missouri’s most celebrated commercial corridors.

138 N Main St, St Charles

$300,000

ACTIVE Status ⋅ Jared Werner

AS-IS Investment property in the heart of historic Frenchtown. Make history by being a part of the ever growing developments revamping the area! Building was previously a commercial open air car wash that was closed in, and has been approved by the city for demo. Proposed development plans circulated, but you can make your own! It's the end cap to the newly renovated Texaco station turned retail and food truck lot with open space and live bands. This spot is situated next to the Katy Trail, minutes from scenic river views, and moments from Historic Main Street Saint Charles. Remediation testing of soil was completed by previous owner and passed. Asbestos testing on building completed and passed as part of the requirement for tear down. Land to build on is rare in this area!

1827 N 2nd St, St Charles

$1,050,000

ACTIVE Status ⋅ Brenda Lowder

Historic Downtown Walking District Adjacent to Kister Park Wide Decking w/River & Park Views Tenant is Riverside Sweets, 2 Apts & Ice cream Shop PSRK STC APP Close to County & City Municipal Buildings: OPO Tech Center, Katy Trail, Hospital & 30 restaurants 15 minutes to St. Louis Int. Airport Sale Price: $1,050,000.00 Lease available: Suite B-1,265sf -$21.13 psf + NNN $5.43

416 S Main St, St Charles

$950,000

ACTIVE Status ⋅ Chris Hill

Run at the opportunity! Prime Industrial Property established in the heart of St. Charles Industrial Zoning. Updated with new office space, new roof and freshly painted. 7,150 SF Office/Warehouse. Located in Established Charlestown Ind Park with Convenient Access to Hwy 94, Hwy 364 & I-70. One Loading Dock (10x12) 1 Drive in Door. 11’ to 12’ 6” Clear height in Warehouse, 2 Private Offices, Break Area & large Reception Area. 100% Temperature Controlled, 600Amp 3 Phase Electric. Zoned I-1 Light Industrial.

1335 Charlestown Industrial Dr, St Charles

$2,450,000

ACTIVE Status ⋅ Chad Wilson

Excellent Investment Opportunity * Great for 1031 Exchange * 100% occupied - Medical Use - Lease expires 2035 * Free Standing Brick Building * Built in 2005 * 32 Parking Spaces * Easy Access to Hwy 364 & Hwy 94

11 Garvey Pkwy, St Charles

$975,000

ACTIVE Status ⋅ Mark Kramer

803 S Main presents a rare opportunity to acquire a premier Main Street property with exceptional versatility. This distinctive building is well-suited for a variety of uses, including mixed-use retail and potential for residential, short-term rentals such as possible Airbnb, event or wedding venue space, and more—all positioned within one of Missouri’s most vibrant and high-traffic tourism corridors. Situated directly on Historic Main Street in St. Charles, the property benefits from consistent foot traffic and outstanding visibility, fueled by year-round festivals and events that draw tens of thousands of visitors each year. The location supports a strong and loyal customer base, proven to have a successful business, and a strong street presence. This is a high-quality asset offering retail opportunity with significant upside potential. It is ideally suited for an owner-operator seeking a retail location, or an experienced investor looking to capitalize on a well-established property with built-in demand, apartment potential for additional income!

803 S Main St, St Charles

$349,000

ACTIVE Status ⋅ Bob Ecker

Two commercial lots being sold together. 2425 and 2431 W. Clay total approximately 2.37 acres. Great frontage along W. Clay and located near Lindenwood University, US Bank, Edward Jones, Plaza Tire, O'Reilly Auto Part, and more. Just minutes from either First Capital Dr., Zumbehl Rd. and Hwy 70. Approximately 210 feet of W. Clay frontage. Location: High Traffic

2425 W Clay St, St Charles

$199,500

ACTIVE Status ⋅ Greg Beckerle

1,560 SF professional office suite located in a well-maintained business park. The space features a large open bullpen area ideal for collaborative workstations, a private office, kitchenette, private restroom, and a generous storage room. The flexible layout makes this property well-suited for a real estate office, campaign headquarters, retail distributor, or a variety of other professional or service-based uses.

918 Hemsath Rd, St Charles

$810,000

ACTIVE Status ⋅ Sherry Ruyle

Discover an exceptional investment opportunity! This portfolio includes four properties— which all of them are currently generating rental income. Two homes have recently been updated. Each ranch-style home features three bedrooms, one bathroom, a kitchen, and a welcoming living room, complemented by a full basement that provides additional storage space. Don’t miss out on this promising opportunity! -

Mulberry Lane (2816, 2820, 2824 & 2828), St Charles

$3,160,000

ACTIVE Status ⋅ Brenda Lowder

1821 S River Rd, St Charles

$2,160,600

ACTIVE Status ⋅ Dee Bax

PROPERTY INFO: City of St. Charles, MO, Zoning: Light Industrial, Visibility and Easy Access to I-370, Levee, Flood Plain and Floodway, Utilities: Sanitary Sewer Main Huster Rd. Water Main at intersection of Huster Rd and Fountain Lakes Blvd. COMMENTS: Property Located in City Wellhead Protection District, Excellent Location for Industrial Development, Daily Vehicle Count: I-370 & Elm St / New Town Blvd - 52,684, Elm St & Elm Point Industrial Dr - 31,749

Huster Rd, St Charles

$440,000

ACTIVE Status ⋅ Rick Meyer

Take advantage of this highly visible .84+/- acre Commercial lot located at 3735 Harry S. Truman Blvd., just off the Cave Springs exit from I-70. Zoned C-3, this versatile property if ideal for retail, food and beverage, a laundromat, or other high-traffic commercial uses. The site includes an existing asphalt parking lot and utilities available to site. Surrounded by thriving businesses - gas stations, restaurants, shopping center, and car dealerships - this location offers excellent exposure and accessibility. With an Average Annual Daily Traffic (AADT) of 6,374, your business will benefit from steady local and commuter traffic along with easy access to I-70. Listed at $12/sq. ft., this is a smart place to build or expand your business in a busy St. Charles corridor.

3735 Harry S Truman Blvd, St Charles

$1,450,000

ACTIVE Status ⋅ Brad Weaver

Excellent development opportunity at the NW corner of Hwy B and Hwy 94. Perfect location for a retail use, C-Store/gas station, etc. The site is located adjacent to the proposed Legacy Farms Park and the Orchard Farm school district campus. Residential development is very prevalent in the area including the New Town and Charlestowne subdivisions. Planned reconfiguration of the Highway B and Highway 94 intersection by MODOT in 2027, to include a lighted intersection with dedicated turn lanes. Currently the site is in Unincorporated St. Charles County, it would need to annex into the City of St. Charles for water/sewer. Multiple older structures (barns, grain bins, houses) on the site, none of which are habitable or provide value.

200 Hwy B St, St Charles

$1,735,430

ACTIVE Status ⋅ Greg Beckerle

Located on Zumbehl Road just north of Highway 94. Zoned C-2 General Business District. All utilities available at site. Excellent road frontage in prime location. This property is contiguous to QuikTrip. Other businesses in area include New Frontier Bank, Walgreen's, Schnucks, Sams, and The St. Charles City Police. Agent is related to owner but is not a principal. Location: High Traffic, Suburban

1501 Zumbehl Rd, St Charles

St Charles Commercial Properties for Sale

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