St Charles Real Estate Search

St Charles Commercial Properties for Sale

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Newest St Charles Commercial Properties for Sale

ACTIVE Status ⋅ Karan Madra

This fully leased multi-tenant retail plaza is a rare opportunity in the highly desirable Saint Charles market. Located along Campus Drive, this established multi-tenant property consists of eight occupied storefronts serving a diverse mix of local businesses, including restaurant, wellness, professional services, chiropractic, beauty, and personal care tenants. The property generates $103,455 in annual gross rental income and delivers a strong Net Operating Income (NOI) of $86,848, providing investors with immediate cash flow and stable in-place tenancy. Monthly rents include CAM reimbursements, helping support consistent operating performance and expense recovery. Strategically positioned in a growing commercial corridor with convenient access to major thoroughfares, the plaza benefits from strong visibility, ample parking, and a tenant roster that serves the surrounding residential and business communities. The diversified tenant mix reduces vacancy risk while creating a dependable income stream for investors seeking a stabilized asset. Whether you are completing a 1031 exchange, expanding your investment portfolio, or seeking a management-friendly commercial asset, this neighborhood retail center offers an attractive combination of income, stability, and upside potential. Offered For Sale – Contact Listing Agent for Pricing, Financials, and Showing Information.

2040 Campus Dr, St Charles

ACTIVE Status ⋅ Jared Werner

AS-IS Investment property in the heart of historic Frenchtown. Make history by being a part of the ever growing developments revamping the area! Building was previously a commercial open air car wash that was closed in, and has been approved by the city for demo. Proposed development plans circulated, but you can make your own! It's the end cap to the newly renovated Texaco station turned retail and food truck lot with open space and live bands. This spot is situated next to the Katy Trail, minutes from scenic river views, and moments from Historic Main Street Saint Charles. Remediation testing of soil was completed by previous owner and passed. Asbestos testing on building completed and passed as part of the requirement for tear down. Land to build on is rare in this area!

1827 N 2nd St, St Charles

ACTIVE Status ⋅ Brenda Lowder

Historic Downtown Walking District Adjacent to Kister Park Wide Decking w/River & Park Views Tenant is Riverside Sweets, 2 Apts & Ice cream Shop PSRK STC APP Close to County & City Municipal Buildings: OPO Tech Center, Katy Trail, Hospital & 30 restaurants 15 minutes to St. Louis Int. Airport Sale Price: $1,050,000.00 Lease available: Suite B-1,265sf -$21.13 psf + NNN $5.43

416 S Main St, St Charles

ACTIVE Status ⋅ Chris Hill

Run at the opportunity! Prime Industrial Property established in the heart of St. Charles Industrial Zoning. Updated with new office space, new roof and freshly painted. 7,150 SF Office/Warehouse. Located in Established Charlestown Ind Park with Convenient Access to Hwy 94, Hwy 364 & I-70. One Loading Dock (10x12) 1 Drive in Door. 11’ to 12’ 6” Clear height in Warehouse, 2 Private Offices, Break Area & large Reception Area. 100% Temperature Controlled, 600Amp 3 Phase Electric. Zoned I-1 Light Industrial.

1335 Charlestown Industrial Dr, St Charles

ACTIVE Status ⋅ Chad Wilson

Excellent Investment Opportunity * Great for 1031 Exchange * 100% occupied - Medical Use - Lease expires 2035 * Free Standing Brick Building * Built in 2005 * 32 Parking Spaces * Easy Access to Hwy 364 & Hwy 94

11 Garvey Pkwy, St Charles

ACTIVE Status ⋅ Greg Beckerle

Professional multi-tenant all brick office building for sale and for lease. Currently 1550sf suite available. Well maintained with long term tenants occupying the building. Suites have been recently updated. HWY 94 visibility. All suites have their own at grade entrances. Monument signs available. Quick and easy access to HWY 94, I-70, and hwy 364 page extension. Call for your private tour today. Agent is related to owner. Location: Business Park, High Traffic, Hwy/Interstate Frntg, Suburban

2085 Bluestone Dr, St Charles

ACTIVE Status ⋅ Leslie Woods

Live/Work Opportunity in the Heart of New Town St. Charles! Don't miss this rare opportunity to own a versatile live/work property in the highly sought- after New Town St. Charles community. Whether you're an investor looking to rent the spaces separately ,live upstairs and rent the commercial space to help with your mortgage, have a Business in commercial and rent condo to help pay your mortgage or looking to run you're own Business steps from home, this property offers incredible flexibility and income potential. The main level features commercial space with a half bath, HVAC, hot water heater, large glass-front entrance for visibility, and a rear door leading to a private driveway, ideal for deliveries, or additional access. Above, you'll find a townhome -style residential unit spanning the second and third levels with it's own secure private entrance. The second floor offers an open living room and kitchen layout, complete with a half bath and access to a deck off the eat -in kitchen, perfect for relaxing or entertaining, listening to the concert at the nearby amphitheater on a weekend. The third level includes two bedrooms, two full bathrooms, and a convenient laundry closet. These properties are rarely available and have consistently rented for the past seven years, with both units just becoming vacant in April 2026-making this a prime opportunity for an owner-occupant or investor. Profit and loss statements are available with a contract offer. Residential rents for $1,850.00 and commercial space $1,200.00. Enjoy all that New Town has to offer, including multiple pools (one with a lazy river), parks, lakes & canals for fishing, playgrounds, and vibrant community spaces. Walk to local favorites like the wine bar, Casa Mia, The District, BobaQue- Restaurants, Bridge coffee shop two doors down, Marsala's grocery, Bonnidell's Ice Cream and many more. Enjoy Live Music at the Amphitheater and many other Events. If you like being active they're is also a fitness center, or enjoy a nice bike ride or walk, it is truly like living in a park.

3245 Domain St, St Charles

ACTIVE Status ⋅ Mark Kramer

803 S Main presents a rare opportunity to acquire a premier Main Street property with exceptional versatility. This distinctive building is well-suited for a variety of uses, including mixed-use retail and potential for residential, short-term rentals such as possible Airbnb, event or wedding venue space, and more—all positioned within one of Missouri’s most vibrant and high-traffic tourism corridors. Situated directly on Historic Main Street in St. Charles, the property benefits from consistent foot traffic and outstanding visibility, fueled by year-round festivals and events that draw tens of thousands of visitors each year. The location supports a strong and loyal customer base, proven to have a successful business, and a strong street presence. This is a high-quality asset offering retail opportunity with significant upside potential. It is ideally suited for an owner-operator seeking a retail location, or an experienced investor looking to capitalize on a well-established property with built-in demand, apartment potential for additional income!

803 S Main St, St Charles

ACTIVE Status ⋅ Stacy Austin

Excellent location, great highway visibility, and quick and easy access to Hwy 364. Commercial, Retail, or Light Industrial - Free Standing Building - over 2,500 SF on nearly an acre. Building has 4 drive-in doors and approximately 40 parking spaces. The billboard located on property is currently leased.

4516 S St Peters Pkwy, St Charles

ACTIVE Status ⋅ Bob Ecker

Two commercial lots being sold together. 2425 and 2431 W. Clay total approximately 2.37 acres. Great frontage along W. Clay and located near Lindenwood University, US Bank, Edward Jones, Plaza Tire, O'Reilly Auto Part, and more. Just minutes from either First Capital Dr., Zumbehl Rd. and Hwy 70. Approximately 210 feet of W. Clay frontage. Location: High Traffic

2425 W Clay St, St Charles

ACTIVE Status ⋅ Greg Beckerle

1,560 SF professional office suite located in a well-maintained business park. The space features a large open bullpen area ideal for collaborative workstations, a private office, kitchenette, private restroom, and a generous storage room. The flexible layout makes this property well-suited for a real estate office, campaign headquarters, retail distributor, or a variety of other professional or service-based uses.

918 Hemsath Rd, St Charles

ACTIVE Status ⋅ Corey Webb

New Roof-2025 Located in the Heart of Main St. between Tony’s on Main & the New Little Nashville Citycentrecomplex.com Virtual Walkthrough available upon request 1st floor Restaurant space occupied by La Tia and Ponchos Cantina Grill Floors 2 & 3 - Retail, Office & Residential Uses Professional Pictures coming soon Location: Downtown, High Traffic

138 N Main St, St Charles

ACTIVE Status ⋅ Sherry Ruyle

Discover an exceptional investment opportunity! This portfolio includes four properties— which all of them are currently generating rental income. Two homes have recently been updated. Each ranch-style home features three bedrooms, one bathroom, a kitchen, and a welcoming living room, complemented by a full basement that provides additional storage space. Don’t miss out on this promising opportunity! -

Mulberry Lane (2816, 2820, 2824 & 2828), St Charles

ACTIVE Status ⋅ Brenda Lowder

1821 S River Rd, St Charles

ACTIVE Status ⋅ Dee Bax

PROPERTY INFO: City of St. Charles, MO, Zoning: Light Industrial, Visibility and Easy Access to I-370, Levee, Flood Plain and Floodway, Utilities: Sanitary Sewer Main Huster Rd. Water Main at intersection of Huster Rd and Fountain Lakes Blvd. COMMENTS: Property Located in City Wellhead Protection District, Excellent Location for Industrial Development, Daily Vehicle Count: I-370 & Elm St / New Town Blvd - 52,684, Elm St & Elm Point Industrial Dr - 31,749

Huster Rd, St Charles

ACTIVE Status ⋅ Rick Meyer

Take advantage of this highly visible .84+/- acre Commercial lot located at 3735 Harry S. Truman Blvd., just off the Cave Springs exit from I-70. Zoned C-3, this versatile property if ideal for retail, food and beverage, a laundromat, or other high-traffic commercial uses. The site includes an existing asphalt parking lot and utilities available to site. Surrounded by thriving businesses - gas stations, restaurants, shopping center, and car dealerships - this location offers excellent exposure and accessibility. With an Average Annual Daily Traffic (AADT) of 6,374, your business will benefit from steady local and commuter traffic along with easy access to I-70. Listed at $12/sq. ft., this is a smart place to build or expand your business in a busy St. Charles corridor.

3735 Harry S Truman Blvd, St Charles

ACTIVE Status ⋅ Brad Weaver

Excellent development opportunity at the NW corner of Hwy B and Hwy 94. Perfect location for a retail use, C-Store/gas station, etc. The site is located adjacent to the proposed Legacy Farms Park and the Orchard Farm school district campus. Residential development is very prevalent in the area including the New Town and Charlestowne subdivisions. Planned reconfiguration of the Highway B and Highway 94 intersection by MODOT in 2027, to include a lighted intersection with dedicated turn lanes. Currently the site is in Unincorporated St. Charles County, it would need to annex into the City of St. Charles for water/sewer. Multiple older structures (barns, grain bins, houses) on the site, none of which are habitable or provide value.

200 Hwy B St, St Charles

ACTIVE Status ⋅ Greg Beckerle

Located on Zumbehl Road just north of Highway 94. Zoned C-2 General Business District. All utilities available at site. Excellent road frontage in prime location. This property is contiguous to QuikTrip. Other businesses in area include New Frontier Bank, Walgreen's, Schnucks, Sams, and The St. Charles City Police. Agent is related to owner but is not a principal. Location: High Traffic, Suburban

1501 Zumbehl Rd, St Charles

ACTIVE Status ⋅ John Cochran

Rare opportunity to own a piece of Historic Main Street St. Charles at a newly adjusted price! Located in the heart of one of the region’s most vibrant commercial districts—featured on The Today Show and known for year-round tourism, festivals, and unbeatable foot traffic—this charming brick storefront offers the perfect blend of income potential and long-term value. All major systems have been updated, including HVAC, electrical, and plumbing, while the 135-year-old building still radiates character with original detailing and paver block frontage. The main level features a bright, inviting showroom, plus a clean kitchen area (fixtures owned by tenant). Bonus features include a mostly finished attic space with approx. 300 sq ft of storage, a deep mop sink, and an additional 31x15 basement area with private exterior access—ideal for future utility, storage, or expansion. Usable outdoor space and access to large public parking lots directly behind the building add extra functionality. Currently leased to Fig & Lyles Bakery, the tenant pays $1,800/month plus utilities, with a lease in place through 12/31/25. Zoned for retail, office, boutique, or food service. Whether you're an investor or a business owner, this is your chance to secure one of the best locations on Historic Main Street!

420 S Main St, St Charles

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